NAD+ (1000MG)

NAD+ 1000MG (Nicotinamide Adenine Dinucleotide, oxidized form) is a critical endogenous coenzyme and cofactor central to cellular energy metabolism and broad enzymatic signaling. As a hydride acceptor, NAD+ participates in core redox reactions across glycolysis, the TCA cycle, fatty acid oxidation, and the mitochondrial electron transport chain. Beyond its role in redox biochemistry, NAD+ functions as a direct substrate for three major classes of NAD+-consuming enzymes: sirtuins (SIRT1–7), which catalyze NAD+-dependent lysine deacylation to regulate transcription, mitochondrial biogenesis, and stress response pathways; poly(ADP-ribose) polymerases (PARPs), which utilize NAD+ in DNA damage sensing and repair signaling cascades; and CD38/CD157 ADP-ribosyl cyclases, which regulate calcium signaling and immune cell function. Notably, cellular NAD+ levels decline with age as salvage pathway activity decreases, making this compound a valuable tool for investigating NAD+-dependent signaling dynamics, sirtuin pathway pharmacology, PARP-mediated genotoxic stress responses, and age-related metabolic pathway modulation in controlled in vitro systems. Supplied at ≥99% purity (HPLC verified).

Store at -20°C to -80°C sealed, or 2-8°C reconstituted for up to 28 days.

This product is sold strictly for research purposes. Not intended for human or animal use. Not FDA-approved.